With the support of this award we will apply two "Next Generation" approaches to the study of genetic mouse models in which specific steps of TORC1 signaling (i.e., via the mTOR/raptor complex itself or the downstream proteins 4EBP1 and S6K1) are selectively altered in key young and old mouse tissues (liver, muscle and brain). The...
Senior and New Scholars Awards for University of Washington
Dr. Peter Rabinovitch
University of Washington
2010 senior Scholar Award in aging
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Dr. Junko Oshima
University of Washington
2007 senior Scholar Award in aging
Progeroid syndromes are groups of diseases in which patients develop features of accelerated aging early in life. Two of the best-known progeroid syndromes are Hutchinson-Gilford progeroid syndrome (HGPS, ìProgeria of Childhoodî) and Werner syndrome (WS, ìProgeria of Adultsî). HGPS is a debilitating child-onset progeria with a median age of...
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Dr. Matt Kaeberlein
University of Washington
2008 new Scholar Award in aging
Studies of the basic mechanisms of aging have led to the identification of many genes modulate life span in model organisms. Despite these advances, however, the molecular mechanism(s) that determine human longevity and susceptibility to age-associated disease remain poorly understood. We have taken a large-scale, multi-organism approach to... |
Dr. Richard Gardner
University of Washington
2009 new Scholar Award in aging
Cellular vitality depends upon the cellís ability to produce functional proteins that carry out important activities essential for life. The duration of a cellís life relies in great part on the cellís ability to maintain its critical cohort of proteins in their functional state. The key pathways within the cell that maintain optimal cellular...
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Dr. Lawrence A. Loeb
University of Washington
1999 senior Scholar Award in aging
Accurate copying of DNA in cells is carried out by DNA polymerases. These enzymes polymerize nulceotides that are complementary to the nucleotides in the cellular DNA template, yielding daughter DNA molecules that preserve the nucleotide sequence of the parental molecules. Errors in this process, if not repaired, result in mutations. Mutations in...
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Dr. David Marcinek
University of Washington
2006 new Scholar Award in aging
Mitochondria play a central role integrating cellular energetics and the control of cell survival. As a result they are a critical element in aging and many degenerative diseases. Our research focuses on identifying the role of in vivo mitochondrial dysfunction in degenerative diseases and aging. We have two primary goals: 1) to... |
Dr. Eitan Glick
University of Washington
2004 new Scholar Award in aging
The decline in energy with age highlights energy metabolism and the role of mitochondria in aging. Aged cells accumulate oxidative DNA damage that is likely to be responsible for the observed increase in mutations, particularly in the mitochondrial genome. The major source of reactive oxygen species (ROS) in the cell is the mitochondria, whose... |
Dr. Weiqing Li
University of Washington
2008 new Scholar Award in aging
Aging is hormonally regulated and we are interested in identifying genetic determinants that function upstream of these endocrine pathways. Recent studies in the nematode Caenorhabditis elegans suggest that altered regulation of steroid and insulin/IGF-1-like hormones can substantially delay organismal aging by triggering pro-survival... |
Dr. Pradipsinh K. Rathod
University of Washington
2002 senior Scholar Award in gid
Malaria kills 1-2 million people every year and causes illness in several 100 million individuals. The hunt for new drugs and vaccines must be complimented with a thorough understanding of how parasites mutate to evade therapeutic measures.
Some clones of the human malarial parasite Plasmodium falciparum may acquire drug resistance... |
Non-Scholar Awards for University of Washington
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2009 Infrastructure Scholar Award in Aging
The Ellison Medical Foundation has awarded $304,683 over two years to support the development of SAGEWEB, a website and resource to promote the exchange of scientific information and enhance fundamental research on the biology of aging. SAGEWEB is a portal to a variety of content, including aging databases, software, educational tools, discussions...
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2005 Infrastructure Scholar Award in Aging
The Ellison Medical Foundation has pledged up to $2,083,261 over 5 years to provide funding for a consortium to identify, verify, and characterize genes that determine longevity across different species from yeast to worms to mouse models. The consortium will develop a systematic library of yeast strains, worm models and mouse strains that will...
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2000 Infrastructure Scholar Award in Aging
Just over $1,000,000 will be awarded over a period of 3 years to support the Telemachus Knowledge Discovery in Aging Resource. This is a project to develop a database and software to search across research disciplines and map research methods, animal models, data from tables and figures, and research results from published literature. This project...
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2008 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $10,000 to provide partial support for The Second International Genome Dynamics in Neuroscience Conference: ìGenome Dynamics and Instability in the Aging Brainî held June 13-17th, 2008 at the Asilomar Conference Grounds in Pacific Grove, California, USA. For further information, see:...
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2005 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $10,000 to support the sessions on ìCancer and Agingî and ìMitochondrial DNA Damage and Human Diseaseî and the symposium on ìEnvironmental DNA Repair and Agingî held at the Environmental Mutagen Societyís Annual Meeting on September 3-8, 2005 in San Francisco, California. For further information, see...
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2002 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $10,000 to help
support the George Martin Symposium: Frontiers of Aging Research. This symposium, in honor of Dr. Martin's 75th birthday and his innumerable contributions to aging... |
Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation