Aging is accompanied and perhaps even defined by a gradual loss in the ability of the organism to respond successfully to fluctuations in the environment and maintain homeostasis. We have discovered that altered activity of the tumor suppressor p53 accelerates this process in the mouse. The function of p53 in normal animals is to control...

One of the most confounding and important problems in understanding malaria concerns the mechanisms by which red blood cells are destroyed. Although it is common knowledge that the malaria parasite, Plasmodium falciparum (Pf), invades red blood cells and causes anemia and severe illness, the percentage of red cells that are infected is...