We have developed two new model systems that lead to significant increases in mouse maximal longevity. One uses a "Crowded Litter" (CL) approach to reduce food availability, but only in the first 3 weeks of life. The other involves genetic ablation of the gene for MIF, a pro-inflammatory cytokine. We propose now to exploit these new models to...
Senior and New Scholars Awards for University of Michigan
Dr. Richard Miller
University of Michigan
2010 senior Scholar Award in aging
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Dr. Jun Li
University of Michigan
2010 new Scholar Award in aging
Aging/longevity is one of the most complex human traits, and is influenced by variations in inherited factors. I will analyze genetic differences of two outbred lines of rat that have been selectively bred for low and high endurance running ability across >26 generations. The low capacity runners and high capacity runners are increasingly...
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Dr. David Lombard
University of Michigan
2009 new Scholar Award in aging
Mitochondria are cytoplasmic organelles that generate the majority of cellular energy and carry out numerous other critical biochemical processes. Mitochondrial dysfunction is implicated in a vast array of severe diseases, including age-associated afflictions; indeed reactive oxygen species generated by mitochondria likely contribute to age-...
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Dr. Sean J. Morrison
University of Michigan
2007 senior Scholar Award in aging
Aging is associated with reduced regeneration and impaired function in a variety of tissues including the brain. Neural stem cells and the formation of new neurons (neurogenesis) persist throughout life in the brain, but decline with age. These declines have been hypothesized to contribute to some types of neurodegeneration and impaired learning...
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Dr. Art Gafni
University of Michigan
2002 senior Scholar Award in aging
A decline in the capacity of living organisms to respond vigorously to external stresses (elevated temperature, damaging radiation, reactive chemical agents, etc.) and to maintain homeostasis is a hallmark of aging and is largely responsible for the age-related increase in mortality. Young cells respond to environmental stresses by... |
Dr. Ao-Lin Hsu
University of Michigan
2005 new Scholar Award in aging
Aging and stress response are both among the most universal of biological processes. Heat-shock Transcription Factor (HSF) is the master regulator of the heat-shock response, a fundamental cellular defensive mechanism against the deleterious effects of various stresses by rapidly expressing a group of proteins known as heat-shock proteins (... |
Non-Scholar Awards for University of Michigan
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2010 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $5,272 to support selected speakers for the "Metabolism, Life History and Aging" Symposium at the 2010 Conference of the Society for Integrative and Comparative Biology held 1/3/10 to 1/7/10 in Seattle, WA. For further information, see:http://www.sicb.org...
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation