Age-associated cognitive decline is a steadily increasing biomedical concern in the US. According to the Administration on Aging over 12% of the United States population is age 65 and older, and by 2030 this estimate is projected to reach 20%. With the average life span increasing, understanding the brain mechanisms that underlie age-associated...

In vitro cellular senescence, since its first description in the literature, has been put forward as a model for aging in species with mitotically active tissues. Evidence suggests that sub-lethal levels of DNA damage, including telomere loss, induce the cellular senescence phenotype in normal human cells. Cellular senescence results in...