Endogenous DNA damage and spontaneous mutagenesis may be important mechanisms in aging. We are developing mouse strains defective in base excision repair (BER) that cannot repair endogenous DNA damage through knockout of the Xrccl scaffold protein. The Xrccl protein interacts with ligase III to coordinate BER and is essential for...
Senior and New Scholars Awards for UCSF Cancer Center
Dr. James E. Cleaver
University of California - San Francisco, UCSF Cancer Center
1999 senior Scholar Award in aging
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation