Aging is associated with an increased risk for cancer and neurodegenerative diseases. These diseases are often caused by a perturbation of the fine balance between protein synthesis, folding, localization, activity and turnover. For example, controlled protein turnover via the ubiquitin-proteasome system prevents the accumulation of ìagedî...

Aging is widely considered to involve a progressive loss of function of mitochondria, the cellular organelles that generate most of the energy required to sustain life. The notion that such mitochondrial dysfunction is not just a consequence, but a cause of aging is the basis of the mitochondrial theory of aging. The precise mechanisms whereby...

The Ellison Medical Foundation has awarded $10,000 to support selected speakers at the Indo-US bilateral conference on "Base Excision DNA Repair, Brain Function and Aging" held January 6-9, 2011 in Hyderabad, India. For further information, see: http://www.uohbif.in/iusw/.