Accurate segregation of chromosomes during mitosis is essential for maintenance of genomic integrity. Errors in this process cause an abnormal chromosome content, known as aneuploidy, which is a hallmark of most human cancers. To test whether aneuploidy is a cause or a consequence of the malignant phenotype, we generated mice that express low...

Decreased insulin-like growth factor (IGF)-I signaling is associated with extended lifespan. However, the underlying mechanisms relating the IGF system and longevity are poorly understood. The IGF system is complex with ubiquitous IGF receptors present on cells to transduce a response, but also with IGF binding proteins (IGFBPs) and IGFBP...