Alzheimer's disease (AD) is the most common form of dementia in the elderly afflicting over 20 million people worldwide. Overwhelming neuropathological and genetic data support the abnormal accumulation and deposition of a small protein called the Aβ peptide as the critical event in AD pathology. Consequently, this peptide has been studied...
Senior and New Scholars Awards for Massachusetts General Hospital
Dr. Rudolph E. Tanzi
Massachusetts General Hospital
2002 senior Scholar Award in aging
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Dr. Anne C. Hart
Massachusetts General Hospital
2006 senior Scholar Award in aging
Aging is observed in all animal species. Studies in vertebrates, insects, nematodes and yeast suggest that conserved biochemical and genetic pathways are involved in lifespan regulation. For example, insulin signaling and sirtuin activity have dramatic effects in longevity across species. However, additional pathways regulate longevity and... |
Dr. Kathryn J. Moore
Massachusetts General Hospital
2003 new Scholar Award in aging
In Alzheimer's disease, a chronic inflammatory response to β-amyloid has been proposed to underly neuro-degenerative pathology. Central to this hypothesis is the observation that microglia are recruited to, and accumulate at, sites of β-amyloid deposition. These cells produce inflammatory mediators capable of inciting chronic... |
Dr. Johnathan Whetstine
Massachusetts General Hospital
2009 new Scholar Award in aging
Genomic stability is a major factor that influences aging and aging-related diseases. The integrity of the genome is influenced by histones and other chromosomal proteins that package and stabilize the genome as well as regulate gene expression. The posttranslational modifications of histones, especially lysine methylation, play an important role...
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Dr. David T. Scadden
Massachusetts General Hospital
2008 senior Scholar Award in aging
Tissue maintenance in most adult organs is driven by the ability of a minor subset of stem/progenitor cells to provide ongoing replenishment of self-limited mature cells. It is known that in the blood, replenishment is impaired with age. We have previously shown that this phenotype of aging is associated with impairment of adult stem cell self-...
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Dr. Jatin M. Vyas
Massachusetts General Hospital
2001 new Scholar Award in gid
Mucosal surfaces represent the interface between host and environment. The gastrointestinal and respiratory tracts extract nutrients from the lumen; however numerous pathogens exist in this milieu that must be excluded. As the first line of defense, copious mucous formation in the respiratory tract serves as a non-specific physical barrier... |
Dr. Eleftherios Mylonakis
Massachusetts General Hospital
2003 new Scholar Award in gid
The significant numbers of serious fungal infections, the paucity of new antifungal agents, and the likelihood of the emergence of drug resistance in fungi, suggest a pressing need for new model systems to study the mechanisms of fungal virulence and host response. Especially cryptococcal meningitis is a relatively common and often fatal...
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Non-Scholar Awards for Massachusetts General Hospital
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2008 Conferences and Workshops Scholar Award in Aging
The Ellison Medical Foundation awarded $5,000 to provide partial support for the session on Neurodegenerative Disorders at The 8th Annual Days of Molecular Medicine Symposium: ìCognitive Dysfunction in Disease: Mechanisms and Therapiesî held April 17-19th, 2008 at The Karolinska Institutet, Stockholm, Sweden . For further information, see:...
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Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation