A major problem during chronological aging is the accumulation of oxidative damage to cellular macromolecules produced by mitochondria-generated reactive oxygen species (ROS). Young cells are protected by a balanced activity of the mitochondria, efficient antioxidant and DNA repair systems, as well as active protein degradation machineries....
Senior and New Scholars Awards for Albert Einstein College of Medicine
Dr. Marion Schmidt
Albert Einstein College of Medicine
Investigation of Proteasome Function in Aging and Oxidative Stress in the Model System S. cerevisiae
2007 new Scholar Award in aging
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Dr. Claire C. Bastie
Albert Einstein College of Medicine
2008 new Scholar Award in aging
Although the body requires sufficient nutrition to function in optimal conditions, mild energy restriction has been shown to improve metabolic disorders, improve cognition and prolong longevity. Thus well-regulated homeostasis appears to be an important factor in increasing lifespan. AMPKinase is important in the control of energy balance and...
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Dr. Erik Lee Snapp
Albert Einstein College of Medicine
2005 new Scholar Award in aging
Misfolded transmembrane and secretory proteins are a feature of several age-associated diseases. The translocation of proteins into the endoplasmic reticulum (ER) and folding are mediated by the translocon and ER chaperones. Oxidative damage of some chaperones in aged tissues suggests folding machinery dysfunction contributes to age-related... |
Funded Institutions
The Ellison Medical Foundation fosters research by means of grants-in-aid on behalf of investigators to universities and laboratories within the United States. Institutions receiving awards must be tax-exempt 501(c)(3) organizations or U.S. colleges or universities.
The Ellison Medical Foundation